November 27, 2019 - Scientists at AbboMax created a panel of TGF-β and TGF-β Receptor antibodies. Transforming growth factor (TGF) superfamily is a large group of structurally related cell regulatory proteins. TGF-β, an evolutionarily conserved pleiotropic polypeptide, regulates multiple biological processes, including adult stem cell differentiation, proliferation, homeostasis, immune regulation, inflammation, wound healing, and embryonic development. TGF-β is involved in activating a number of signal pathways, including the SMAD family of transcription factors that regulate gene expression. SMAD2 and SMAD3 are downstream proteins in the TGF-β signaling pathway that translocate signals from the cell membrane to the nucleus, bind DNA, and control the expression of target genes.

Multiple cells synthesize TGF-β and many cells have specific receptors for this peptide. TGF-β signal through a highly restricted subset of receptors known as TGF-β receptors, a family of serine/threonine kinase receptors. Three types of TGF-β family receptors, type I, type II, and type III, can be distinguished by their structural and functional properties. TGF-β binds with high affinity to its receptor type II, a transmembrane protein with a cytoplasmic serine/threonine kinase domain, to form a dynamic dimer with phosphorylation in the cytoplasmic Ser/Thr residuals which cause its kinase activity and association with another TGF beta-binding protein, the type I receptor, to signal growth inhibition and early gene responses. Receptors I and II associate as interdependent components of a heteromeric complex: receptor I requires receptor II to bind TGF-β, and receptor II requires receptor I to signal.

A panel of TGF-β and TGF-β Receptor antibodies:

Anti-TGF beta
Anti-TGF beta 1
Anti-TGF beta 2
Anti-TGF beta R1 (Anti-TGFBR 1)
Anti-TGF beta Receptor II (Anti-TGFBR II)
Anti-TGF beta Receptor III (Anti-TGFBR III)
Anti-TGFBR 1 (nonphospho)
Anti-TGFBR. 1 (phospho) (pS187, 189, and 191)
Anti-TGFBR 1 (pS165)

AbboMax has been developing & manufacturing high performance immunoassay reagents for many years in California. The company specializes in high-quality custom service and products focusing on polyclonal, phosphospecific antibodies, IHC grade monoclonal antibodies, FFPE cell pellets slides, tissue/cell blocks and CRO services.
By Natasha Raysberg, Ph.D.

Contact Information
Natasha Raysberg
Abbomax,inc.
2528 Qume Dr #8
2528 Qume Dr #8
95131
Voice: 408-573-1898